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KMID : 0923620130130050218
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Immune Network
2013 Volume.13 No. 5 p.218 ~ p.221
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B Cells Promote Th1- Skewed NKT Cell Response by CD1d-TCR Interaction
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Shin Jung-Hoon
Park Se-Ho
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Abstract
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CD1d expressing dendritic cells (DCs) are good glyco-lipid antigen presenting cells for NKT cells. However, resting B cells are very weak stimulators for NKT cells. Although ?-galactosylceramide (?-GalCer) loaded B cells can activate NKT cells, it is not well defined whether B cells interfere NKT cell stimulating activity of DCs. Unexpectedly, we found in this study that B cells can promote Th1-skewed NKT cell response, which means a increased level of IFN-? by NKT cells, concomitant with a decreased level of IL-4, in the circumstance of co-culture of DCs and B Cells. Remarkably, the response promoted by B cells was dependent on CD1d expression of B cells.
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KEYWORD
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B cells, Dendritic cells, NKT cells, α-galactosylceramide and Th1 response
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